KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo

Kaposi's sarcoma herpesvirus (KSHV)-encoded v-cyclin, a homolog of cellular cyclin D2, activates cellular CDK6, promotes G1-S transition of the cell cycle, induces DNA damage, apoptosis, autophagy and is reported to have oncogenic potential. Here we show that in vivo expression of v-cyclin in t...

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Bibliografske podrobnosti
izdano v:Cell Cycle
Main Authors: Pekkonen, Pirita, Järviluoma, Annika, Zinovkina, Nadezhda, Cvrljevic, Anna, Prakash, Sonam, Westermarck, Jukka, Evan, Gerard I, Cesarman, Ethel, Verschuren, Emmy W, Ojala, Päivi M
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2014
Teme:
Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613844/
https://ncbi.nlm.nih.gov/pubmed/25483078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.964118
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