Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation

Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood. We show here that exposure of expansively growing human WM852 melanoma cells, but not singly invasiv...

詳細記述

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書誌詳細
出版年:eLife
主要な著者: Pekkonen, Pirita, Alve, Sanni, Balistreri, Giuseppe, Gramolelli, Silvia, Tatti-Bugaeva, Olga, Paatero, Ilkka, Niiranen, Otso, Tuohinto, Krista, Perälä, Nina, Taiwo, Adewale, Zinovkina, Nadezhda, Repo, Pauliina, Icay, Katherine, Ivaska, Johanna, Saharinen, Pipsa, Hautaniemi, Sampsa, Lehti, Kaisa, Ojala, Päivi M
フォーマット: Artigo
言語:Inglês
出版事項: eLife Sciences Publications, Ltd 2018
主題:
Cancer Biology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5929907/
https://ncbi.nlm.nih.gov/pubmed/29712618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.32490
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