PROX1 is a transcriptional regulator of MMP14

The transcription factor PROX1 is essential for development and cell fate specification. Its function in cancer is context-dependent since PROX1 has been shown to play both oncogenic and tumour suppressive roles. Here, we show that PROX1 suppresses the transcription of MMP14, a metalloprotease invol...

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Pubblicato in:Sci Rep
Autori principali: Gramolelli, Silvia, Cheng, Jianpin, Martinez-Corral, Ines, Vähä-Koskela, Markus, Elbasani, Endrit, Kaivanto, Elisa, Rantanen, Ville, Tuohinto, Krista, Hautaniemi, Sampsa, Bower, Mark, Haglund, Caj, Alitalo, Kari, Mäkinen, Taija, Petrova, Tatiana V., Lehti, Kaisa, Ojala, Päivi M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6015061/
https://ncbi.nlm.nih.gov/pubmed/29934628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27739-w
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