Phosphorylation of NF-κB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination

The nuclear factor-kappaB (NF-κB) transcription factor system is a crucial component that controls several important biological functions, thus raising the need for mechanisms that ensure the correct termination of its activity. Here, we identify a new phosphorylation/ubiquitination switch in the NF...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Geng, Hui, Wittwer, Tobias, Dittrich-Breiholz, Oliver, Kracht, Michael, Schmitz, Michael Lienhard
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2009
Sujets:
Scientific Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2672889/
https://ncbi.nlm.nih.gov/pubmed/19270718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.10
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