Action Potential Clamp and Pharmacology of the Variant 1 Short QT Syndrome T618I hERG K(+) Channel

BACKGROUND: The familial Short QT Syndrome (SQTS) is associated with an increased risk of cardiac arrhythmia and sudden death. Gain-of-function mutations in the hERG K(+) channel protein have been linked to variant 1 of the SQTS. A hERG channel pore (T618I) mutation has recently been identified in f...

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Bibliographic Details
Main Authors: El Harchi, Aziza, Melgari, Dario, Zhang, Yi Hong, Zhang, Henggui, Hancox, Jules C.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530446/
https://ncbi.nlm.nih.gov/pubmed/23300672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052451
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