IGF-1R Signaling in Chondrocytes Modulates Growth Plate Development by Interacting With the PTHrP/Ihh Pathway

Systemic derangements and perinatal death of generalized insulin-like growth factor 1 (IGF-1) and IGF-1 receptor (IGF-1R) knockout mice preclude definitive assessment of IGF-1R actions in growth-plate (GP) chondrocytes. We generated cartilage-specific Igf1r knockout ((Cart)Igf1r(−/−)) mice to invest...

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Bibliografiset tiedot
Päätekijät: Wang, Yongmei, Cheng, Zhiqiang, ElAlieh, Hashem Z, Nakamura, Eiichiro, Nguyen, Minh-Thanh, Mackem, Susan, Clemens, Thomas L, Bikle, Daniel D, Chang, Wenhan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530140/
https://ncbi.nlm.nih.gov/pubmed/21312270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.359
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