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IGF-1R Signaling in Chondrocytes Modulates Growth Plate Development by Interacting With the PTHrP/Ihh Pathway
Systemic derangements and perinatal death of generalized insulin-like growth factor 1 (IGF-1) and IGF-1 receptor (IGF-1R) knockout mice preclude definitive assessment of IGF-1R actions in growth-plate (GP) chondrocytes. We generated cartilage-specific Igf1r knockout ((Cart)Igf1r(−/−)) mice to invest...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3530140/ https://ncbi.nlm.nih.gov/pubmed/21312270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.359 |
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