Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP

In the developing growth plate, periarticular chondrocytes proliferate, differentiate into columnar chondrocytes, and then further differentiate into postmitotic hypertrophic chondrocytes. Parathyroid hormone–related (PTH-related) protein (PTHrP), regulated by Indian hedgehog (Ihh), prevents prematu...

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Autores principales: Kobayashi, Tatsuya, Soegiarto, Desi W., Yang, Yingzi, Lanske, Beate, Schipani, Ernestina, McMahon, Andrew P., Kronenberg, Henry M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2005
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1143590/
https://ncbi.nlm.nih.gov/pubmed/15951842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24397
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