Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP

In the developing growth plate, periarticular chondrocytes proliferate, differentiate into columnar chondrocytes, and then further differentiate into postmitotic hypertrophic chondrocytes. Parathyroid hormone–related (PTH-related) protein (PTHrP), regulated by Indian hedgehog (Ihh), prevents prematu...

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Detalhes bibliográficos
Main Authors: Kobayashi, Tatsuya, Soegiarto, Desi W., Yang, Yingzi, Lanske, Beate, Schipani, Ernestina, McMahon, Andrew P., Kronenberg, Henry M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1143590/
https://ncbi.nlm.nih.gov/pubmed/15951842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24397
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