Tetramethylenedisulfotetramine Alters Ca(2+) Dynamics in Cultured Hippocampal Neurons: Mitigation by NMDA Receptor Blockade and GABA(A) Receptor-Positive Modulation

Tetramethylenedisulfotetramine (TETS) is a potent convulsant that is considered a chemical threat agent. We characterized TETS as an activator of spontaneous Ca(2+) oscillations and electrical burst discharges in mouse hippocampal neuronal cultures at 13–17 days in vitro using FLIPR Fluo-4 fluoresce...

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Autors principals: Cao, Zhengyu, Hammock, Bruce D., McCoy, Mark, Rogawski, Michael A., Lein, Pamela J., Pessah, Isaac N.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529644/
https://ncbi.nlm.nih.gov/pubmed/22889812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfs244
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