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Structural Requirements for the Antiproliferative Activity of Pre-mRNA Splicing Inhibitor FR901464
FR901464 is a natural product isolated from a bacterium source that activates a reporter gene, inhibits pre-mRNA splicing, and shows antitumor activity. We previously reported the development of a more potent analogue, meayamycin, through the total synthesis of FR901464. Herein, we report detailed s...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3529175/ https://ncbi.nlm.nih.gov/pubmed/21226105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201002402 |
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