Meayamycin Inhibits pre-mRNA Splicing and Exhibits Picomolar Activity Against Multidrug Resistant Cells

FR901464 is a potent antitumor natural product that binds to the SF3b complex and inhibits pre-mRNA splicing. Its analogue, meayamycin, is two orders of magnitude more potent as an antiproliferative agent against human breast cancer MCF-7 cells. Here, we report the picomolar antiproliferative activi...

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Detalhes bibliográficos
Main Authors: Albert, Brian J., McPherson, Peter A., O'Brien, Kristine, Czaicki, Nancy L., DeStefino, Vincent, Osman, Sami, Li, Miaosheng, Day, Billy W., Grabowski, Paula J., Moore, Melissa J., Vogt, Andreas, Koide, Kazunori
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762647/
https://ncbi.nlm.nih.gov/pubmed/19671752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0051
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