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Total Syntheses, Fragmentation Studies, and Antitumor/Antiproliferative Activities of FR901464 and Its Low Picomolar Analog

FR901464 is a potent anticancer natural product that lowers the mRNA levels of oncogenes and tumor suppressor genes. In this article, we report a convergent enantioselective synthesis of FR901464, which was accomplished in 13 linear steps. Central to the synthetic approach was the diene-ene cross ol...

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Autors principals: Albert, Brian J., Sivaramakrishnan, Ananthapadmanabhan, Naka, Tadaatsu, Czaicki, Nancy L., Koide, Kazunori
Format: Artigo
Idioma:Inglês
Publicat: 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2530894/
https://ncbi.nlm.nih.gov/pubmed/17279752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja067870m
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