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Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing
Two unrelated bacterial natural products, FR901464 and pladienolide B, have previously been shown to have significant anti-tumor activity in vivo. These compounds target the SF3b subunit of the spliceosome, with a derivative of pladienolide (E7107) entering clinical trials for cancer. However, due t...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3113647/ https://ncbi.nlm.nih.gov/pubmed/21344922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb100356k |
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