Mechanism of 5′ Topoisomerase II DNA adduct repair by mammalian Tyrosyl DNA phosphodiesterase 2 (Tdp2)

The Topoisomerase II (topo II) DNA incision and ligation cycle can be poisoned (e.g following treatment with cancer chemotherapeutics) to generate cytotoxic DNA double strand breaks (DSBs) with topo II covalently conjugated to DNA. Tyrosyl-DNA phosphodiesterase 2 (Tdp2) protects genomic integrity by...

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Detaylı Bibliyografya
Asıl Yazarlar: Schellenberg, Matthew J., Appel, C. Denise, Adhikari, Sanjay, Robertson, Patrick D., Ramsden, Dale A., Williams, R. Scott
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529160/
https://ncbi.nlm.nih.gov/pubmed/23104055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2418
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