Mechanism of 5′ Topoisomerase II DNA adduct repair by mammalian Tyrosyl DNA phosphodiesterase 2 (Tdp2)

The Topoisomerase II (topo II) DNA incision and ligation cycle can be poisoned (e.g following treatment with cancer chemotherapeutics) to generate cytotoxic DNA double strand breaks (DSBs) with topo II covalently conjugated to DNA. Tyrosyl-DNA phosphodiesterase 2 (Tdp2) protects genomic integrity by...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Schellenberg, Matthew J., Appel, C. Denise, Adhikari, Sanjay, Robertson, Patrick D., Ramsden, Dale A., Williams, R. Scott
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529160/
https://ncbi.nlm.nih.gov/pubmed/23104055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2418
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker