Reversal of DNA damage induced Topoisomerase 2 DNA–protein crosslinks by Tdp2

Mammalian Tyrosyl-DNA phosphodiesterase 2 (Tdp2) reverses Topoisomerase 2 (Top2) DNA–protein crosslinks triggered by Top2 engagement of DNA damage or poisoning by anticancer drugs. Tdp2 deficiencies are linked to neurological disease and cellular sensitivity to Top2 poisons. Herein, we report X-ray...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Schellenberg, Matthew J., Perera, Lalith, Strom, Christina N., Waters, Crystal A., Monian, Brinda, Appel, C. Denise, Vilas, Caroline K., Williams, Jason G., Ramsden, Dale A., Williams, R. Scott
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857006/
https://ncbi.nlm.nih.gov/pubmed/27060144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw228
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