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The composition and signaling of the IL-35 receptor are unconventional
Interleukin-35 (IL-35) belongs to the IL-12 family of heterodimeric cytokines but has a distinct functional profile. IL-35 suppresses T cell proliferation and converts naïve T cells into IL-35-producing iTr35. Here we show that IL-35 signals through a unique IL-12Rβ2:gp130 heterodimer or via homodim...
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Main Authors: | , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3529151/ https://ncbi.nlm.nih.gov/pubmed/22306691 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2227 |
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