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Orai-STIM–mediated Ca(2)(+) release from secretory granules revealed by a targeted Ca(2+) and pH probe

Secretory granules (SGs) sequester significant calcium. Understanding roles for this calcium and potential mechanisms of release is hampered by the difficulty of measuring SG calcium directly in living cells. We adapted the Förster resonance energy transfer-based D1-endoplasmic reticulum (ER) probe...

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Bibliografiske detaljer
Main Authors: Dickson, Eamonn J., Duman, Joseph G., Moody, Mark W., Chen, Liangyi, Hille, Bertil
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529049/
https://ncbi.nlm.nih.gov/pubmed/23184982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218247109
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