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Golgi and plasma membrane pools of PI(4)P contribute to plasma membrane PI(4,5)P(2) and maintenance of KCNQ2/3 ion channel current

Plasma membrane (PM) phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)] regulates the activity of many ion channels and other membrane-associated proteins. To determine precursor sources of the PM PI(4,5)P(2) pool in tsA-201 cells, we monitored KCNQ2/3 channel currents and translocation of PH(PLCδ1...

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Detalhes bibliográficos
Main Authors: Dickson, Eamonn J., Jensen, Jill B., Hille, Bertil
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050574/
https://ncbi.nlm.nih.gov/pubmed/24843134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407133111
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