Rational Design of Bioactive, Modularly Assembled Aminoglycosides Targeting the RNA that Causes Myotonic Dystrophy Type 1

Myotonic dystrophy type 1 (DM1) is caused when an expanded r(CUG) repeat (r(CUG)(exp)) binds the RNA splicing regulator muscleblind-like 1 protein (MBNL1) as well as other proteins. Previously, we reported that modularly assembled small molecules displaying a 6′-N-5-hexynoate kanamycin A RNA-binding...

Full description

Saved in:
Bibliographic Details
Main Authors: Childs-Disney, Jessica L., Parkesh, Raman, Nakamori, Masayuki, Thornton, Charles A., Disney, Matthew D.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528830/
https://ncbi.nlm.nih.gov/pubmed/23130637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb3001606
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items