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Optimising Immunogenicity with Viral Vectors: Mixing MVA and HAdV-5 Expressing the Mycobacterial Antigen Ag85A in a Single Injection

The Bacillus Calmette - Guerin (BCG) vaccine provides a critical but limited defense against Mycobacterium tuberculosis (M.tb). More than 60 years after the widespread introduction of BCG, there is an urgent need for a better vaccine. A large body of pre-clinical research continues to support ongoin...

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Autors principals: Betts, Gareth, Poyntz, Hazel, Stylianou, Elena, Reyes-Sandoval, Arturo, Cottingham, Matthew, Hill, Adrian, McShane, Helen
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528774/
https://ncbi.nlm.nih.gov/pubmed/23284637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050447
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