Evaluation of the Safety and Immunogenicity of a Candidate Tuberculosis Vaccine, MVA85A, Delivered by Aerosol to the Lungs of Macaques

Tuberculosis (TB) is a reemerging disease. The only available vaccine, Mycobacterium bovis BCG, is delivered intradermally and confers highly variable efficacy against pulmonary disease. There is an urgent need for improved vaccination strategies. Murine studies suggest that immunizations delivered...

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Autors principals: White, A. D., Sibley, L., Dennis, M. J., Gooch, K., Betts, G., Edwards, N., Reyes-Sandoval, A., Carroll, M. W., Williams, A., Marsh, P. D., McShane, H., Sharpe, S. A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2013
Matèries:
Vaccines
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647747/
https://ncbi.nlm.nih.gov/pubmed/23446219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00690-12
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