β-Arrestin–biased agonism as the central mechanism of action for insulin-like growth factor 1 receptor–targeting antibodies in Ewing’s sarcoma

Owing to its essential role in cancer, insulin-like growth factor type 1 receptor (IGF-1R)–targeted therapy is an exciting approach for cancer treatment. However, when translated into clinical trials, IGF-1R–specific antibodies did not fulfill expectations. Despite promising clinical responses in Ew...

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Hlavní autoři: Zheng, Huiyuan, Shen, Hongchang, Oprea, Iulian, Worrall, Claire, Stefanescu, Radu, Girnita, Ada, Girnita, Leonard
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528604/
https://ncbi.nlm.nih.gov/pubmed/23188799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216348110
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