Differential trapping of PARP1 and PARP2 by clinical PARP inhibitors

Small molecule inhibitors of polyADP-ribose polymerase (PARP) are thought to mediate their antitumor effects as catalytic inhibitors that block repair of DNA single strand breaks. However, the mechanism of action of PARP inhibitors with regard to their effects in cancer cells is not fully understood...

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Main Authors: Murai, Junko, Huang, Shar-yin N., Das, Benu Brata, Renaud, Amelie, Zhang, Yiping, Doroshow, James H., Ji, Jiuping, Takeda, Shunichi, Pommier, Yves
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528345/
https://ncbi.nlm.nih.gov/pubmed/23118055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-2753
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