Amalgamation of Nucleosides and Amino Acids in Antibiotic Biosynthesis: Discovery of an L-Threonine:Uridine-5'-Aldehyde Transaldolase

The lipopeptidyl nucleoside antibiotics reperesented by A-90289, caprazamycin, and muraymycin, are structurally highlighted by a nucleoside core that contains a nonproteinogenic β-hydroxy-α-amino acid named 5′-C-glycyluridine (GlyU). Bioinformatic analysis of the biosynthetic gene clusters revealed...

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Autores principales: Barnard-Britson, Sandra, Chi, Xiuling, Nonaka, Koichi, Spork, Anatol P., Tibrewal, Nidhi, Goswami, Anwesha, Pahari, Pallab, Ducho, Christian, Rohr, Jurgen, Van Lanen, Steven G.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528340/
https://ncbi.nlm.nih.gov/pubmed/23110675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja308185q
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