PTEN regulates TLR5-induced intestinal inflammation by controlling Mal/TIRAP recruitment

Defective IL-10 allele is a risk factor for intestinal inflammation. Indeed, IL-10(−/−) mice are predisposed to spontaneous colitis in the presence of intestinal microbiota, indicating that microbial factors contribute to developing intestinal inflammation. By recognizing flagellin, TLR5 plays a qui...

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Bibliografiske detaljer
Main Authors: Choi, Yoon Jeong, Jung, Jane, Chung, Hyo Kyun, Im, Eunok, Rhee, Sang Hoon
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2013
Fag:
Research Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528317/
https://ncbi.nlm.nih.gov/pubmed/23038756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-217596
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