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Autotaxin loss accelerates intestinal inflammation by suppressing TLR4‐mediated immune responses

Autotaxin (ATX) converts lysophosphatidylcholine and sphingosyl‐phosphorylcholine into lysophosphatidic acid and sphingosine 1‐phosphate, respectively. Despite the pivotal function of ATX in lipid metabolism, mechanisms by which ATX regulates immune and inflammatory disorders remain elusive. Here, u...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Kim, Su Jin, Howe, Cody, Mitchell, Jonathon, Choo, Jieun, Powers, Alexandra, Oikonomopoulos, Angelos, Pothoulakis, Charalabos, Hommes, Daniel W, Im, Eunok, Rhee, Sang Hoon
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7534615/
https://ncbi.nlm.nih.gov/pubmed/32875703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201949332
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