Autotaxin loss accelerates intestinal inflammation by suppressing TLR4‐mediated immune responses

Autotaxin (ATX) converts lysophosphatidylcholine and sphingosyl‐phosphorylcholine into lysophosphatidic acid and sphingosine 1‐phosphate, respectively. Despite the pivotal function of ATX in lipid metabolism, mechanisms by which ATX regulates immune and inflammatory disorders remain elusive. Here, u...

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Vydáno v:EMBO Rep
Hlavní autoři: Kim, Su Jin, Howe, Cody, Mitchell, Jonathon, Choo, Jieun, Powers, Alexandra, Oikonomopoulos, Angelos, Pothoulakis, Charalabos, Hommes, Daniel W, Im, Eunok, Rhee, Sang Hoon
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7534615/
https://ncbi.nlm.nih.gov/pubmed/32875703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201949332
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