A Promising Vector for TCR Gene Therapy: Differential Effect of siRNA, 2A Peptide, and Disulfide Bond on the Introduced TCR Expression

Adoptive immunotherapy using TCR gene-modified T-lymphocytes is an attractive strategy for targeting malignancies. However, TCR mispairings between endogenous and introduced TCR chains are a major concern, as they may induce mixed TCRs with unknown specificities and may reduce the expression of ther...

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Bibliographic Details
Main Authors: Okamoto, Sachiko, Amaishi, Yasunori, Goto, Yumi, Ikeda, Hiroaki, Fujiwara, Hiroshi, Kuzushima, Kiyotaka, Yasukawa, Masaki, Shiku, Hiroshi, Mineno, Junichi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528300/
https://ncbi.nlm.nih.gov/pubmed/23250361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2012.52
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