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A Promising Vector for TCR Gene Therapy: Differential Effect of siRNA, 2A Peptide, and Disulfide Bond on the Introduced TCR Expression
Adoptive immunotherapy using TCR gene-modified T-lymphocytes is an attractive strategy for targeting malignancies. However, TCR mispairings between endogenous and introduced TCR chains are a major concern, as they may induce mixed TCRs with unknown specificities and may reduce the expression of ther...
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Auteurs principaux: | , , , , , , , , |
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Format: | Artigo |
Langue: | Inglês |
Publié: |
Nature Publishing Group
2012
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Sujets: | |
Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3528300/ https://ncbi.nlm.nih.gov/pubmed/23250361 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2012.52 |
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