The STAT5 Inhibitor Pimozide Displays Efficacy in Models of Acute Myelogenous Leukemia Driven by FLT3 Mutations

Activation of the transcription factor STAT5 is essential for the pathogenesis of acute myelogenous leukemia (AML) containing the FLT3 internal tandem duplication (ITD) mutation. FLT3 ITD is a constitutively active tyrosine kinase that drives the activation of STAT5, leading to the growth and surviv...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Nelson, Erik A., Walker, Sarah R., Xiang, Michael, Weisberg, Ellen, Bar-Natan, Michal, Barrett, Rosemary, Liu, Suiyang, Kharbanda, Surender, Christie, Amanda L., Nicolais, Maria, Griffin, James D., Stone, Richard M., Kung, Andrew L., Frank, David A.
Format: Artigo
Jezik:Inglês
Izdano: SAGE Publications 2012
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527989/
https://ncbi.nlm.nih.gov/pubmed/23264850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601912466555
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki