The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors

The transcription factor STAT5 is an essential mediator of the pathogenesis of chronic myelogenous leukemia (CML). In CML, the BCR/ABL fusion kinase causes the constitutive activation of STAT5, thereby driving the expression of genes promoting survival. BCR/ABL kinase inhibitors have become the main...

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Detalhes bibliográficos
Main Authors: Nelson, Erik A., Walker, Sarah R., Weisberg, Ellen, Bar-Natan, Michal, Barrett, Rosemary, Gashin, Laurie B., Terrell, Shariya, Klitgaard, Josephine L., Santo, Loredana, Addorio, Martha R., Ebert, Benjamin L., Griffin, James D., Frank, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069678/
https://ncbi.nlm.nih.gov/pubmed/21233313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-11-255232
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