The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors

The transcription factor STAT5 is an essential mediator of the pathogenesis of chronic myelogenous leukemia (CML). In CML, the BCR/ABL fusion kinase causes the constitutive activation of STAT5, thereby driving the expression of genes promoting survival. BCR/ABL kinase inhibitors have become the main...

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Bibliografiska uppgifter
Huvudupphovsmän: Nelson, Erik A., Walker, Sarah R., Weisberg, Ellen, Bar-Natan, Michal, Barrett, Rosemary, Gashin, Laurie B., Terrell, Shariya, Klitgaard, Josephine L., Santo, Loredana, Addorio, Martha R., Ebert, Benjamin L., Griffin, James D., Frank, David A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2011
Ämnen:
Myeloid Neoplasia
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069678/
https://ncbi.nlm.nih.gov/pubmed/21233313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-11-255232
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