The STAT5 Inhibitor Pimozide Displays Efficacy in Models of Acute Myelogenous Leukemia Driven by FLT3 Mutations

Activation of the transcription factor STAT5 is essential for the pathogenesis of acute myelogenous leukemia (AML) containing the FLT3 internal tandem duplication (ITD) mutation. FLT3 ITD is a constitutively active tyrosine kinase that drives the activation of STAT5, leading to the growth and surviv...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Nelson, Erik A., Walker, Sarah R., Xiang, Michael, Weisberg, Ellen, Bar-Natan, Michal, Barrett, Rosemary, Liu, Suiyang, Kharbanda, Surender, Christie, Amanda L., Nicolais, Maria, Griffin, James D., Stone, Richard M., Kung, Andrew L., Frank, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2012
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527989/
https://ncbi.nlm.nih.gov/pubmed/23264850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601912466555
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados