The RING Finger Protein RNF8 Ubiquitinates Nbs1 to Promote DNA Double-strand Break Repair by Homologous Recombination

Ubiquitination plays an important role in the DNA damage response. We identified a novel interaction of the E3 ubiquitin ligase RNF8 with Nbs1, a key regulator of DNA double-strand break (DSB) repair. We found that Nbs1 is ubiquitinated both before and after DNA damage and is a direct ubiquitination...

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Autores principales: Lu, Chi-Sheng, Truong, Lan N., Aslanian, Aaron, Shi, Linda Z., Li, Yongjiang, Hwang, Patty Yi-Hwa, Koh, Kwi Hye, Hunter, Tony, Yates, John R., Berns, Michael W., Wu, Xiaohua
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527981/
https://ncbi.nlm.nih.gov/pubmed/23115235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.421545
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