The Glaucoma-associated Olfactomedin Domain of Myocilin Is a Novel Calcium Binding Protein

Myocilin is a protein found in the trabecular meshwork extracellular matrix tissue of the eye that plays a role in regulating intraocular pressure. Both wild-type and certain myocilin variants containing mutations in the olfactomedin (OLF) domain are linked to the optic neuropathy glaucoma. Because...

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Bibliographic Details
Main Authors: Donegan, Rebecca K., Hill, Shannon E., Turnage, Katherine C., Orwig, Susan D., Lieberman, Raquel L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527924/
https://ncbi.nlm.nih.gov/pubmed/23129764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.408906
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