Antifolate Activity of Isoaminopterin in HeLa Cells
The antifolate activity and the transport characteristics of isoaminopterin (IA) in HeLa cells were studied and compared with those of methotrexate (MTX). Both IA and MTX inhibited the incorporation of [2-(14)C]deoxyuridine into HeLa cell DNA by 50% at a concentration of 0.09 μM by 8 h postaddition...
Gardado en:
| Publicado en: | Antimicrob Agents Chemother |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology (ASM)
1979
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352745/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/525990/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.15.5.730 |
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