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A Novel Role of IL-2 in Organ-Specific Autoimmune Inflammation beyond Regulatory T Cell Checkpoint: Both IL-2 Knockout and Fas Mutation Prolong Lifespan of Scurfy Mice but by Different Mechanisms()

Mutation of the Foxp3 transcription factor in Scurfy (Sf) mice results in complete absence of the CD4(+)Foxp3(+) regulatory T cells (Tregs), severe multiorgan autoimmune syndrome, and early death at 4 wk of age. However, Sf mice simultaneously bearing the Il2(−/−) (Sf.Il2(−/−)) or Fas(lpr/lpr) gene...

詳細記述

保存先:
書誌詳細
主要な著者: Zheng, Lingjie, Sharma, Rahul, Gaskin, Felicia, Fu, Shu Man, Ju, Shyr-Te
フォーマット: Artigo
言語:Inglês
出版事項: 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527098/
https://ncbi.nlm.nih.gov/pubmed/18056343
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