IL-2 Regulates CD103 Expression on CD4(+) T cells in Scurfy Mice That Display Both CD103-Dependent and Independent Inflammation

Scurfy (Sf) mice lack CD4(+)Foxp3(+) regulatory T cells (Treg) and develop fatal multi-organ inflammation (MOI) mediated by CD4(+) T cells. Introducing Il2(-/-) gene into Sf mice (Sf.Il2(-/-)) inhibited inflammation in skin and lung. As a major integrin receptor for the organs, we compared CD103 exp...

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Main Authors: Sharma, Rahul, Sung, Sun-sang Joe, Abaya, Christian E., Ju, Angela Chiao-Ying, Fu, Shu Man, Ju, Shyr-Te
Format: Artigo
Language:Inglês
Published: 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734909/
https://ncbi.nlm.nih.gov/pubmed/19553521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0804354
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