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The Biology of Autoimmune Response in the Scurfy Mice that Lack the CD4(+)Foxp3(+) Regulatory T-Cells
Due to a mutation in the Foxp3 transcription factor, Scurfy mice lack regulatory T-cells that maintain self-tolerance of the immune system. They develop multi-organ inflammation (MOI) and die around four weeks old. The affected organs are skin, tail, lungs and liver. In humans, endocrine and gastroi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4011033/ https://ncbi.nlm.nih.gov/pubmed/24832045 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biology1010018 |
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