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IL-2 Regulates CD103 Expression on CD4(+) T cells in Scurfy Mice That Display Both CD103-Dependent and Independent Inflammation
Scurfy (Sf) mice lack CD4(+)Foxp3(+) regulatory T cells (Treg) and develop fatal multi-organ inflammation (MOI) mediated by CD4(+) T cells. Introducing Il2(-/-) gene into Sf mice (Sf.Il2(-/-)) inhibited inflammation in skin and lung. As a major integrin receptor for the organs, we compared CD103 exp...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2734909/ https://ncbi.nlm.nih.gov/pubmed/19553521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0804354 |
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