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A single progenitor population switches behavior to maintain and repair esophageal epithelium

Diseases of esophageal epithelium (EE) such as reflux esophagitis and cancer are rising in incidence. Despite this, the cellular behaviors underlying EE homeostasis and repair remain controversial. Here we show that in mice, EE is maintained by a single population of cells that divide stochastically...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Doupé, David P., Alcolea, Maria P., Roshan, Amit, Zhang, Gen, Klein, Allon M., Simons, Benjamin D., Jones, Philip H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527005/
https://ncbi.nlm.nih.gov/pubmed/22821983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1218835
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