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Protonation State of a Conserved Acidic Amino Acid Involved in Na(+) Binding to the Glutamate Transporter EAAC1

[Image: see text] Substrate transport by glutamate transporters is coupled to the co-transport of 3 Na(+) ions and counter-transport of 1 K(+) ion. The highly conserved Asp454, which may be negatively charged, is of interest as its side chain may coordinate cations and/or contribute to charge compen...

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Detalhes bibliográficos
Main Authors: Mwaura, Juddy, Tao, Zhen, James, Herbert, Albers, Thomas, Schwartz, Alexander, Grewer, Christof
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526966/
https://ncbi.nlm.nih.gov/pubmed/23259042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn300163p
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