An integrative computational systems biology approach identifies differentially regulated dynamic transcriptome signatures which drive the initiation of human T helper cell differentiation

BACKGROUND: A proper balance between different T helper (Th) cell subsets is necessary for normal functioning of the adaptive immune system. Revealing key genes and pathways driving the differentiation to distinct Th cell lineages provides important insight into underlying molecular mechanisms and n...

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Main Authors: Äijö, Tarmo, Edelman, Sanna M, Lönnberg, Tapio, Larjo, Antti, Kallionpää, Henna, Tuomela, Soile, Engström, Emilia, Lahesmaa, Riitta, Lähdesmäki, Harri
格式: Artigo
語言:Inglês
出版: BioMed Central 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526425/
https://ncbi.nlm.nih.gov/pubmed/23110343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-13-572
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