Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease

There is extensive evidence that cholesterol and membrane lipids play a key role in Alzheimer disease (AD) pathogenesis. Cyclodextrins (CD) are cyclic oligosaccharide compounds widely used to bind cholesterol. Because CD exerts significant beneficial effects in Niemann-Pick type C disease, which sha...

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Bibliographic Details
Main Authors: Yao, Jiaqi, Ho, Daniel, Calingasan, Noel Y., Pipalia, Nina H., Lin, Michael T., Beal, M. Flint
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526350/
https://ncbi.nlm.nih.gov/pubmed/23209315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121239
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