Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer’s disease

In Alzheimer’s disease (AD), oxidative stress is present early and contributes to disease pathogenesis. We previously reported that in Tg19959 transgenic AD mice, partial deficiency of the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD) exacerbated amyloid pathology. We there...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Dumont, Magali, Wille, Elizabeth, Stack, Cliona, Calingasan, Noel Y., Beal, M. Flint, Lin, Michael T.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Federation of American Societies for Experimental Biology 2009
Aiheet:
Research Communications
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717785/
https://ncbi.nlm.nih.gov/pubmed/19346295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-132928
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia