Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer’s disease

In Alzheimer’s disease (AD), oxidative stress is present early and contributes to disease pathogenesis. We previously reported that in Tg19959 transgenic AD mice, partial deficiency of the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD) exacerbated amyloid pathology. We there...

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Detalhes bibliográficos
Main Authors: Dumont, Magali, Wille, Elizabeth, Stack, Cliona, Calingasan, Noel Y., Beal, M. Flint, Lin, Michael T.
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2009
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717785/
https://ncbi.nlm.nih.gov/pubmed/19346295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-132928
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