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Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition
Mitochondrial dysfunction and oxidative stress are involved in Alzheimer’s disease (AD) pathogenesis. In human AD brains, the α-ketoglutarate dehydrogenase enzyme complex activity (α-KGDHC) is reduced. KGDHC is mostly involved in NADH production. It can also participate in oxidative stress and react...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2009
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2761144/ https://ncbi.nlm.nih.gov/pubmed/19596066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2009.07.008 |
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