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Sequence-specific cleavage of the RNA strand in DNA–RNA hybrids by the fusion of ribonuclease H with a zinc finger

Ribonucleases (RNases) are valuable tools applied in the analysis of RNA sequence, structure and function. Their substrate specificity is limited to recognition of single bases or distinct secondary structures in the substrate. Currently, there are no RNases available for purely sequence-dependent f...

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Hlavní autoři: Sulej, Agata A., Tuszynska, Irina, Skowronek, Krzysztof J., Nowotny, Marcin, Bujnicki, Janusz M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526281/
https://ncbi.nlm.nih.gov/pubmed/23042681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks885
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