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Improving selectivity of DNA–RNA binding zinc finger using directed evolution
OBJECTIVE: Type C2H2 zinc fingers bind a variety of substrates, specific sequences in the double-stranded DNA counting among them. Engineering efforts led to the discovery of a set of general rules that enable obtaining zinc fingers modules that bind to almost any given sequence. The objective of th...
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| Udgivet i: | BMC Res Notes |
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| Hovedforfatter: | |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6894256/ https://ncbi.nlm.nih.gov/pubmed/31801592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13104-019-4833-8 |
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