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Catalytic Mechanism of RNA Backbone Cleavage by Ribonuclease H from QM/MM Simulations
We use quantum mechanics/molecular mechanics (QM/MM) simulations to study the cleavage of the ribonucleic acid (RNA) backbone catalyzed by ribonuclease H. This protein is a prototypical member of a large family of enzymes that use two-metal catalysis to process nucleic acids. By combining Hamiltonia...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3110985/ https://ncbi.nlm.nih.gov/pubmed/21539371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja200173a |
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