EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes turmorigenesis

Many types of human tumor cells have overexpressed pyruvate kinase M2 (PKM2). However, the mechanism underlying this increased PKM2 expression remains to be defined. We demonstrate here that EGFR activation induces PLCγ1-dependent PKCε monoubiquitylation at Lys321 mediated by RINCK1 ubiquitin ligase...

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Bibliografiske detaljer
Main Authors: Yang, Weiwei, Xia, Yan, Cao, Yu, Zheng, Yanhua, Bu, Wen, Zhang, Lin, You, M. James, Koh, Mei Yee, Cote, Gilbert, Aldape, Kenneth, Li, Yi, Verma, Inder M., Chiao, Paul J, Lu, Zhimin
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526114/
https://ncbi.nlm.nih.gov/pubmed/23123196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.09.028
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